The Hidden Pathway to Peak Performance.

Prevail is built on a well-established body of human performance research surrounding dietary nitrates and nitric oxide.

WHAT ARE DIETARY NITRATES?

Dietary nitrates are naturally occurring compounds found in certain vegetables.

Dietary nitrates are converted in the body through a 3-Step process:

  • Nitrate is first reduced to nitrite by oral bacteria
  • Nitrite is then converted into nitric oxide (NO) in blood and muscle tissue
  • Nitric oxide plays a central role in regulating blood flow and oxygen delivery

This nitrate–nitrite–nitric oxide pathway has been extensively characterized in human physiology and exercise science literature.

Nitrate
Nitrite
Nitric Oxide

Physiological Roles of Nitric Oxide in Exercise

Research has identified several mechanisms through which nitric oxide influences exercise performance:

Vasodilation

Increases blood vessel diameter, improving blood flow to working muscle

Oxygen efficiency

Reduces the oxygen cost of submaximal exercise

Mitochondrial efficiency

Improves energy production at the cellular level

Calcium handling

Supports muscle contraction efficiency

Fatigue resistance

Delays onset of muscular fatigue under repeated effort

Research & Evidence

Independent, peer-reviewed studies supporting dietary nitrate supplementation and nitric oxide research.

Dietary Nitrate Supplementation and Exercise Performance

Jones AM. Dietary Nitrate Supplementation and Exercise Performance. Sports Medicine. 2014.
This review synthesizes research on inorganic nitrate and exercise, showing that nitrate converts to nitrite and nitric oxide in humans and is associated with improved blood flow and performance outcomes in various exercise modalities — particularly endurance-related efforts
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Reduced oxygen cost of exercise

Bailey SJ, et al. Dietary nitrate supplementation reduces the oxygen cost of low-intensity exercise. Journal of Applied Physiology. 2009.
This controlled human trial found dietary nitrate intake lowered the oxygen requirement during submaximal exercise and increased time to exhaustion, indicating improved oxygen efficiency and endurance.
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The effects of dietary nitrate supplementation on endurance.

C Gao, et al. The effects of dietary nitrate supplementation on endurance. Journal of the International Society of Sports Nutrition. 2021.
A systematic review and meta-analysis showing nitrate supplementation improved performance-related outcomes in endurance sports — including reductions in oxygen cost and increases in time to exhaustion and power output across multiple studies.
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Meta-analysis — high-intensity exercise

Alsharif NS, Clifford T, Alhebshi A, Rowland SN, Bailey SJ. Effects of Dietary Nitrate Supplementation on Performance during Single and Repeated Bouts of Short-Duration High-Intensity Exercise: A Systematic Review and Meta-Analysis. Antioxidants. 2023.
This meta-analysis found that nitrate supplementation had small positive effects on performance outcomes such as peak power and total distance covered in high-intensity exercise efforts; effects vary by duration and dosing.
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Dietary Nitrate Supplementation Enhances High-Intensity Intermittent Exercise Performance

Cermak NM, et al. Dietary nitrate supplementation improves sprint and high-intensity intermittent exercise performance. European Journal of Applied Physiology, 2018.
This article summarizes findings from a peer-reviewed human study investigating the effects of dietary nitrate supplementation on performance in repeated high-intensity intermittent exercise.
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Physiological mechanisms — skeletal muscle & oxygen efficiency

Macuh M, et al. Effects of Nitrate Supplementation on Exercise Physiology and Performance. PMCID. 2021.
This paper details mechanisms by which nitrate intake influences skeletal muscle, blood vessels, and mitochondrial respiration, potentially reducing ATP cost of contraction and oxygen consumption during exercise.
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Why Nitrate Standardization Matters

Nitrate content in whole foods varies widely depending on growing conditions, storage, and processing.

Research protocols require known, repeatable nitrate doses to produce reliable outcomes.

Prevail uses a standardized red spinach extract to ensure consistent nitrate delivery aligned with studied ranges.

Most clinical trials use quantified nitrate doses, making standardization necessary for reproducible outcomes

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Supporting Nutrients in the Formula

Dietary nitrates function through vascular and cellular mechanisms that are sensitive to hydration status, electrolyte balance, and neuromuscular signaling.

For that reason, Prevail includes a minimal set of supporting nutrients — such as electrolytes and naturally occurring potassium — to support fluid balance, nerve transmission, and cardiovascular function during exercise.

These ingredients are not intended to stimulate performance directly, but to ensure the nitrate–nitric oxide pathway can function effectively under physical stress.

No artificial stimulants, vasodilators, or unnecessary compounds are included.

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